Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model
نویسندگان
چکیده
منابع مشابه
TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice
BACKGROUND Toll-like receptor 4 (TLR4) has been implicated in inflammation-induced bone destruction in various chronic bone diseases; however, its direct influence on bone healing is not well understood. The authors' previous study showed accelerated bone healing with higher osteoclastogenesis gene expression in toll-like receptor 4 knockout mice (TLR4). This study aimed to further elucidate th...
متن کاملSerotonin-mediated thrombosis and selective serotonin re-uptake inhibition.
Thromb Haemost 2009; 102: 424–425 Since the classification of platelet agonists into strong and weak began, controversy has surrounded the role of serotonin in the amplification of the generation of platelet-rich thrombi in arterial disease. Interest in serotonin-mediated platelet thrombosis stems from the detailed investigations of de Clerck and the Janssen group (1, 2). The paper by Galan et ...
متن کاملSelective COX-2 inhibitor reduces bone healing in bone defects.
Anti-inflammatory agents have been reported to regulate bone healing. The aim of this study was to investigate the effect of a selective cyclooxygenase-2 inhibitor (meloxicam) on bone healing in calvarial defects in rats. Thirty-six adult male Wistar rats were included. After anesthesia, a linear incision was made through the skin of the scalp, a full-thickness flap was reflected and a 4 mm rou...
متن کاملEnhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 - 2006.
Depression is a major psychiatric disorder. It affects millions of people worldwide and inflicts tremendous economic burden on societies. The advent of selective serotonin re-uptake inhibitors as antidepressants has been a revolutionary advance in the treatment of depression and related disorders. However, selective serotonin re-uptake inhibitors are also associated with several undesirable pro...
متن کاملDiamond Squid (Thysanoteuthis rhombus)-Derived Chondroitin Sulfate Stimulates Bone Healing within a Rat Calvarial Defect
Chondroitin sulfate (CS) has been suggested to be involved in bone formation and mineralization processes. A previous study showed that squid-derived CS (sqCS) has osteoblastogenesis ability in cooperation with bone morphogenetic protein (BMP)-4 in vitro. However, in vivo, osteogenic potential has not been verified. In this study, we created a critical-sized bone defect in the rat calvaria and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Oral Science
سال: 2018
ISSN: 2049-3169
DOI: 10.1038/s41368-018-0026-x